Description

mutational signature deconvolution of cancer cells

Input

Name
Description
Pattern

0 ()

1 ()

genome (string)

Reference genome name to use with SigProfiler (e.g. "GRCh37", "GRCh38")

genome_installed_path (file)

path to installed reference genome (optional)

Output

Name
Description
Pattern

0 ()

0 ()

Tools

sigprofilermatrixgenerator Documentation

Sigprofilermatrixgenerator is a Python-based tool. It creates mutational matrices for all types of somatic mutations (SBS, DBS, and IDs)

https://github.com/AlexandrovLab/SigProfilerMatrixGenerator/tree/master/SigProfilerMatrixGeneratordoi: 10.1186/s12864-019-6041-2License: BSD-2-clause

sigprofilerextractor Documentation

SigProfilerExtractor is a Python-based tool. It allows de novo extraction of mutational signatures from data generated in a matrix format, identification of the number of operative mutational signatures, and their activities in each sample.

https://github.com/AlexandrovLab/SigProfilerExtractordoi: 10.1016/j.xgen.2022.100179 License: BSD-2-clause
Authors